Release Date: 2024-06-05
Flash Radiation Therapy: Current Insights and Future Prospects
Osman Vefa Gul (Author)
Release Date: 2024-06-05
FLASH radiotherapy (RT) is an innovative approach used in cancer treatment. The FLASH effect is observed at ultra-high dose rates (UHDR) of approximately 40 Gy/s or higher. This treatment method has the potential to effectively destroy tumor cells while causing less damage to healthy tissues. It has been shown that FLASH irradiation reduces the severity [...]
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| Work Type | Book Chapter |
|---|---|
| Published in | The Latest Innovative Approaches in Radiation Therapy |
| First Page | 81 |
| Last Page | 132 |
| DOI | https://doi.org/10.69860/nobel.9786053359425.5 |
| Page Count | 52 |
| Copyright Holder | Nobel Tıp Kitabevleri |
| License | https://nobelpub.com/publish-with-us/copyright-and-licensing |
The types of energy used in FLASH RT are generally similar to those used in CONV RT, but they are applied at much higher dose rates. FLASH RT requires special technology to deliver radiation at high dose rates. These technologies include Linear Accelerators (LINAC), Proton Accelerators and Carbon Ion Accelerators. The main types of energy that can be used in FLASH RT are Electrons, Protons, X-rays, and Carbon ions. Currently, studies aiming to use electrons, protons and X-rays in UHDR transmission methods are ongoing. Among these studies are those that focus on the use of 100-200 MeV very high energy electrons (VHEE) to target deep-located tumors with FLASH RT using electrons. There are also studies on proton FLASH RT, which aim to take advantage of the physical properties of protons called Bragg peaks. This book chapter on FLASH RT covers promising FLASH RT technologies, FLASH radiobiology, patient treatments with FLASH RT, and radiation dosimetry of FLASH RT. FLASH RT is considered a revolutionary innovation in cancer treatment. Advances in technological and biological research indicate that this treatment method could lead to wider clinical applications.
Osman Vefa Gul (Author)
Assistant Professor, Selcuk University
https://orcid.org/0000-0002-6773-3132
3Asst. Prof. Dr. Osman Vefa GUL graduated from Gazi University, Department of Physics in 2010. He completed his master’s and doctoral theses on prostate radiotherapy and adaptive radiotherapy in head and neck cancers, respectively. He has been working as a medical physicist in the radiotherapy clinic since 2010. He worked as a lecturer at Selcuk University between 2017-2023. Since 2023, he has been working as an Assistant Professor Dr. at Selcuk University. He has international articles, book chapters, and international presentations on IMRT, Tomotherapy, Brachytherapy, the effect of dose rate in radiotherapy applications, radiology, thermoluminescence dosimetry, and other radiation dosimetry systems. He has given many lectures in the fields of medical physics, radiology, and radiation dosimetry. His interests include FLASH radiotherapy, in vivo dosimetry, brachytherapy, diagnostic, and therapeutic radiation applications.
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Wu Y, No HJ, MBreitkreutz DY, Mascia AE, Moeckli R, Bourhis J, Schüler E, Maxim PG & Loo BW Jr. (2021). Technological Basis for Clinical Trials in FLASH Radiation Therapy: A Review. Appl Rad Oncol. (2):6-14.
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