Pathogenesis
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Idiopathic pulmonary fibrosis is characterized by an aberrant wound healing response following lung injury, leading to excessive fibroblast proliferation and extracellular matrix deposition. Fibroblasts and myofibroblasts play a central role in the disease process. They proliferate abnormally and produce collagen and other matrix proteins, resulting in fibrosis. Epithelial-mesenchymal transition where epithelial cells transform into mesenchymal [...]
