Release Date: 2024-06-19

Aspiration Pneumonia in Children

Helin Nerede (Author), Menduh Oruc (Author)

Release Date: 2024-06-19

Idiopathic pulmonary fibrosis is characterized by an aberrant wound healing response following lung injury, leading to excessive fibroblast proliferation and extracellular matrix deposition. Fibroblasts and myofibroblasts play a central role in the disease process. They proliferate abnormally and produce collagen and other matrix proteins, resulting in fibrosis. Epithelial-mesenchymal transition where epithelial cells transform into mesenchymal [...]

Media Type
    Buy from

    Price may vary by retailers

    Work TypeBook Chapter
    Published inPediatric Chest Infection
    First Page139
    Last Page147
    DOIhttps://doi.org/10.69860/nobel.9786053359463.14
    Page Count9
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Idiopathic pulmonary fibrosis is characterized by an aberrant wound healing response following lung injury, leading to excessive fibroblast proliferation and extracellular matrix deposition. Fibroblasts and myofibroblasts play a central role in the disease process. They proliferate abnormally and produce collagen and other matrix proteins, resulting in fibrosis. Epithelial-mesenchymal transition where epithelial cells transform into mesenchymal cells, contributes to the pool of fibroblasts in the fibrotic lung. Mutations in genes related to telomere maintenance (TERT, TERC) and surfactant proteins (SFTPC, SFTPA2) have been linked to familial and sporadic idiopathic pulmonary fibrosis cases. Environmental triggers as exposure to environmental factors such as cigarette smoke, occupational dusts, and viral infections may trigger or exacerbate the disease in genetically predisposed individuals. The hallmark pattern seen in IPF is Usual Interstitial Pneumonia (UIP) that includes patchy fibrosis that occurs in a heterogeneous, patchy distribution within the lung. Honeycombing characterized by formation of cystic spaces lined by bronchiolar epithelium, typically found in subpleural and paraseptal regions. Fibroblastic foci comprised of clusters of proliferating fibroblasts and myofibroblasts at the leading edge of fibrotic areas. Temporal and spatial heterogeneity with the presence of normal lung, early (fibroblastic foci) and late (honeycombing) lesions within the same lung biopsy, indicating ongoing disease activity.

    Helin Nerede (Author)
    Dicle University
    https://orcid.org/0009-0004-8673-1214
    3Dr.Helin Nerede completed her education at Dıcle Unıversity,school of medicine from 2016 to 2022. She worked as a general practitioner at Selahaddin Eyyubi State Hospital between 2022-2023. For specializing in department of children healt and diseases she started to work at Dıcle Unıversity Faculty of Medicine , department of Pediatrics in 2023 for specialization in Pediatrics. Currently , she serves as the Dicle Unıversity Faculty of Medicine, department of Pediatrics Faculty of Medicine,in Diyarbakır,Turkey.

    Menduh Oruc (Author)
    Associate Professor, Dicle University
    https://orcid.org/0000-0001-5778-385X
    3Menduh ORUÇ completed his undergraduate education at Dicle University Faculty of Medicine between 1996-2001 and his thoracic surgery specialization at Dicle University Faculty of Medicine between 2004-2009. He started his academic career as an assistant professor at Dicle University Faculty of Medicine in 2013. He received the title of associate professor in 2019 and still continues as an academic staff member at the same university. Dr.Menduh ORUÇ is a member of the Turkish Thoracic Surgery Association, Turkish Thoracic Association, Turkish Respiratory Research Association, Turkish Lung Cancers Association, Turkish Pulmonary Hydatidology Association and EACTS. Skills:He plays chess well, speaks Turkish at a very good level, as well as English at an intermediate level.Apart from these, he focuses on agriculture and plants as a hobby.

    • W.H.O. Pneumonia 2019 [updated August 2, 2019 Available from: https://www.who.int/news-room/ fact-sheets/detail/pneumonia.

    • Johanson WG:Intraduction to pneumonia.Cecil textbook of medicine (19 .ed)Vol.1 W.B Saunders Company philadelphia.p.409-413.2002.

    • Alataş F. Aspirasyon pnömonisi ve akciğer absesi. İç: Özlü T, Metintaş M, Karadağ M, Kaya A, ed. Solunum Sistemi Hastalıkları. 1. baskı. İstanbul: İstanbul Tıp Kitapevi; 2010: 961-8.

    • Marik PE. Aspiration pneumonitis and aspiration pneumonia. N Engl J Med 2001; 344: 665-71.

    • Marik PE. Pulmonary aspiration syndromes. Current Opinion in Pulmonary Medicine 2011; 17:148- 154.

    • Finegold SM. Aspiration pneumonia. Reviews of Infectious Diseases 1991;13(Suppl 9):S737-S742.

    • Marik PE. Pulmonary aspiration syndromes. Current Opinion in Pulmonary Medicine 2011; 17:148- 154.

    • Janda M, Scheeren TWL, Nöldge-Schomburg GFE. Management of pulmonary aspiration. Best Practice & Research Clinical Anaesthesiology 2006;20:409-427

    • Platzker AC. Gastroesophageal reflux and aspiration syndromes. Kendig’s disorders of the respiratory tract in children, 2006: 592-609.

    • Aschraft KW, Goodwin C ,Amoury RA,Holder TM:Early recognition and agressive treatment of gastroesophageal reflukx follwing repair of esophageal atresia.J Pediatr Sur.1997:12:317-321.

    • Furuya ME, Martinez J Zuniga-Vasquez G,Hernandez-contreras I:Lipoid pnemonia İn children.Clinical and imagenolical manifestations.Arch Med Res 2000:31:42-47.

    • El-Solh AA, Vora H, Knight PR 3rd, Porhomayon J. Diagnostic utilty of serum procalcitonin levels in pulmonary aspiration syndromes. Crit care Med 2011; 39: 1251-6.

    • Tomita Y, Sugimoto M, Kawano O, Kohrogi H. High incidence of false-positive aspergillus galactomannan test results in patients with aspiration pneumonia. J Am Geriatr Soc 2009; 57: 935-6.

    • Bai C, Liu J, Song Y. Amylase in broncoalveolar lavage fluid: a new marker for pulmonary aspiration. Crit Care Med 2013; 41: 916-7.

    • Simpson AJ, Allen JL, Chatwin M, Crawford H, Elverson J, Ewan V., ... & Legg, J. BTS clinical statement on aspiration pneumonia. Thorax, 2023: 78(Suppl 1), s3-s21.

    • Ping LAM. Aspiration pneumonitis and aspiration pneumonia in neurologically impaired children. J Ped Respir Crit Care 2008: 4, 3-7.

    • Seddon PC, Khan Y. Respiratory problems in children with neurological impairment. Arch Dis Child 2003;88:75-8

    • Rebuck JA, Rasmussen JR, Olsen KM. Clinical aspirationrelated practice patterns in the intensive care unit: a physician survey. Crit Care Med 2001;29:2239-44.

    • Marik PE. Aspiration pneumonitis and aspiration pneumonia. N Eng J Med 2001;344:665-71

    • Brook I. Anaerobic pulmonary infections in children. Pediatr Emerg Care 2004;20:636-40.

    • Takamizawa S, Tsugawa C, Nishijima E, Muraji T, Satoh S. Laryngotracheal separation for intractable aspiration pneumonia in neurologically impaired children: experience with 11 cases. J Pediatr Surg 2003;38:975-7.

    • Ewan VC, Sails AD, Walls AWG, et al. Dental and microbiological risk factors for hospital-acquired pneumonia in non-ventilated older patients. PLoS One 2015;10:e0123622.

    onix_3.0::thothThoth ONIX 3.0
    onix_3.0::project_museProject MUSE ONIX 3.0
    onix_3.0::oapenOAPEN ONIX 3.0
    onix_3.0::jstorJSTOR ONIX 3.0
    onix_3.0::google_booksGoogle Books ONIX 3.0
    onix_3.0::overdriveOverDrive ONIX 3.0
    onix_2.1::ebsco_hostEBSCO Host ONIX 2.1
    csv::thothThoth CSV
    json::thothThoth JSON
    kbart::oclcOCLC KBART
    bibtex::thothThoth BibTeX
    doideposit::crossrefCrossRef DOI deposit
    onix_2.1::proquest_ebraryProQuest Ebrary ONIX 2.1
    marc21record::thothThoth MARC 21 Record
    marc21markup::thothThoth MARC 21 Markup
    marc21xml::thothThoth MARC 21 XML

    Share This Chapter!