his chapter presents a comprehensive review of the psychopharmacology of depression. It discusses the prevalence and impacts of depression, emphasizing that antidepressant drugs are effective treatments. Starting from traditional treatments like monoamine oxidase inhibitors (MAO-Is) and tricyclic antidepressants (TCAs), it moves on to newer options like selective serotonin reuptake inhibitors (SSRIs) and selective serotonin-norepinephrine reuptake inhibitors (SNRIs). Additionally, other antidepressant classes and novel experiential treatments are explored. Moreover, it mentions the effectiveness of adjunctive therapies alongside antidepressants, noting their lower tolerability. Lastly, it discusses future directions in depression treatment, particularly highlighting promising new options like glutamate receptor modulators.