Release Date: 2024-06-19

Immunotherapy for Prostate Cancer

Ilkin Hamid-Zada (Author), Ozgur Arikan (Author)

Release Date: 2024-06-19

In this section, we reviewed immunotherapy for metastatic castration-resistant PCa (mCRPC), which is a promising area of research. Sipuleucel-T, a vaccine, showed some survival benefit but limited PSA decline. Other vaccines and immune checkpoint inhibitors are being tested with mixed results. CAR-T cell therapy, where T cells are engineered to target cancer cells, is also [...]

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    Work TypeBook Chapter
    Published inCurrent Management of Metastatic Prostate Cancer
    First Page131
    Last Page139
    DOIhttps://doi.org/10.69860/nobel.9786053359142.13
    Page Count9
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
    In this section, we reviewed immunotherapy for metastatic castration-resistant PCa (mCRPC), which is a promising area of research. Sipuleucel-T, a vaccine, showed some survival benefit but limited PSA decline. Other vaccines and immune checkpoint inhibitors are being tested with mixed results. CAR-T cell therapy, where T cells are engineered to target cancer cells, is also under investigation. More studies are needed to determine the best immunotherapies for PCa.

    Ilkin Hamid-Zada (Author)
    MD, Istanbul Medeniyet University
    https://orcid.org/0009-0000-0550-250X
    3Ilkin Hamid-zada works as a urology resident in the Urology Department of Istanbul Medeniyet University. He participated in many congresses and scientific studies. He is particularly interested in the field of uro-oncology.

    Ozgur Arikan (Author)
    MD, Istanbul Medeniyet University
    https://orcid.org/0000-0002-4647-4864
    3Ozgur Arikan has contributed to numerous scientific studies, book chapters, and academic assignments with a decade of experience as a urology specialist at various institutions. Currently, he continues his work at the Department of Urology in Istanbul Medeniyet University.

    • Graff JN, Liang LW, Kim J, Stenzl A. KEYNOTE-641: a Phase III study of pembrolizumab plus enzalutamide for metastatic castration-resistant prostate cancer. Future Oncol. 2021 Aug;17(23):3017-3026.

    • Rizzo A, Mollica V, Cimadamore A, Santoni M, Scarpelli M, Giunchi F, Cheng L, Lopez-Beltran A, Fiorentino M, Montironi R, Massari F. Is There a Role for Immunotherapy in Prostate Cancer? Cells. 2020 Sep 8;9(9):2051.

    • Ferretti S, Mercinelli C, Marandino L, Litterio G, Marchioni M, Schips L. Metastatic Castration-Resistant Prostate Cancer: Insights on Current Therapy and Promising Experimental Drugs. Res Rep Urol. 2023 Jun 26;15:243-259.

    • Powles T, Yuen KC, Gillessen S, Kadel EE 3rd, Rathkopf D, Matsubara N, Drake CG, Fizazi K, Piulats JM, Wysocki PJ, Buchschacher GL Jr, Alekseev B, Mellado B, Karaszewska B, Doss JF, Rasuo G, Datye A, Mariathasan S, Williams P, Sweeney CJ. Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial. Nat Med. 2022 Jan;28(1):144-153.

    • Rastogi I, Muralidhar A, McNeel DG. Vaccines as treatments for prostate cancer. Nat Rev Urol. 2023 Sep;20(9):544-559. doi: 10.1038/s41585-023-00739-w. Epub 2023 Mar 6.

    • Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, Redfern CH, Ferrari AC, Dreicer R, Sims RB, Xu Y, Frohlich MW, Schellhammer PF; IMPACT Study Investigators. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010 Jul 29;363(5):411-22.

    • Rathi N, McFarland TR, Nussenzveig R, Agarwal N, Swami U. Evolving Role of Immunotherapy in Metastatic Castration Refractory Prostate Cancer. Drugs. 2021 Feb;81(2):191-206.

    • van den Eertwegh AJ, Versluis J, van den Berg HP, Santegoets SJ, van Moorselaar RJ, van der Sluis TM, Gall HE, Harding TC, Jooss K, Lowy I, Pinedo HM, Scheper RJ, Stam AG, von Blomberg BM, de Gruijl TD, Hege K, Sacks N, Gerritsen WR. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol. 2012 May;13(5):509-17.

    • Schepisi G, Farolfi A, Conteduca V, Martignano F, De Lisi D, Ravaglia G, Rossi L, Menna C, Bellia SR, Barone D, Gunelli R, De Giorgi U. Immunotherapy for Prostate Cancer: Where We Are Headed. Int J Mol Sci. 2017 Dec 5;18(12):2627.

    • Antonarakis ES, Piulats JM, Gross-Goupil M, Goh J, Ojamaa K, Hoimes CJ, Vaishampayan U, Berger R, Sezer A, Alanko T, de Wit R, Li C, Omlin A, Procopio G, Fukasawa S, Tabata KI, Park SH, Feyerabend S, Drake CG, Wu H, Qiu P, Kim J, Poehlein C, de Bono JS. Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study. J Clin Oncol. 2020 Feb 10;38(5):395-405.

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