Release Date: 2024-06-12

Brain and Oxidative Stress

Songul Cetik Yildiz (Author)

Release Date: 2024-06-12

Brain tissue is more sensitive to oxidative damage due to many different properties than other tissues. So, the need for protection of brain tissue, which is more prone to oxidative damage than other tissues and organs, is greater than other tissues. Oxidative stress is brought on by a disturbance in the balance between antioxidants and [...]

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    Work TypeBook Chapter
    Published inBrain Biochemistry and Its Disease
    First Page149
    Last Page165
    DOIhttps://doi.org/10.69860/nobel.9786053359371.9
    Page Count17
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Brain tissue is more sensitive to oxidative damage due to many different properties than other tissues. So, the need for protection of brain tissue, which is more prone to oxidative damage than other tissues and organs, is greater than other tissues. Oxidative stress is brought on by a disturbance in the balance between antioxidants and free radicals, which have a scavenging effect on them in biological systems. Increased ROS causes cell damage by causing damage to cell membranes, deterioration in the structure and functions of intracellular proteins, and structural damage to DNA. Oxidative stress is responsible for the pathogenesis of many diseases, especially cancer, diabetes, neurological and cardiovascular diseases, atherosclerosis and inflammatory disorders. Brain tissue is prone to free radical damage because it produces more toxic radicals than other organs. Because the brain has a poorer antioxidant defense system and a higher oxidative metabolism than other organs, it is more vulnerable to ROS-induced damage that can lead to neuronal death. Regional differences in antioxidant system activities and variable metabolic rates in brain tissue may also cause regional accumulation of oxidative damage. In the light of this information, it is aimed to evaluate oxidative stress, the mechanism of oxidative stress formation and the mechanisms of action of oxidative stress on the brain, its effects on intracellular structures and the destruction products formed in oxidative stress with the results of biochemical studies.

    Songul Cetik Yildiz (Author)
    Assistant Professor, Mardin Artuklu University
    https://orcid.org/0000-0002-7855-5343
    3I graduated from Eskişehir Osmangazi University, Department of Biology (2005-2009). I also completed my master’s degree (2009-2011) and doctorate (2011-2014) education at Eskişehir Osmangazi University, Department of Biology. I have been working as an academician at Mardin Artuklu University since 2012. Throughout my academic life, I have carried out multidisciplinary projects with experimental studies. We aimed to benefit from the antitumor antioxidant and probiotic properties of alternative agents against multi-organ toxicity, mostly caused by cancer drugs. We evaluated possible oxidative stress parameters and apoptotic markers by measuring all parameters, especially biochemical and genetic. I am currently working as an assistant professor at the same university.

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