Release Date: 2024-01-23

Fat Soluble Vitamins and Macrominerals

Elif Polat (Author)

Release Date: 2024-01-23

The word vitamin was first used to mean ""the amine necessary for life"". • Vitamins are organic catalysts necessary for normal body functions, growth and healthy living. They are not synthesized in the human body and must be obtained externally. Vitamins are classified according to their fat and water solubility. Fat-soluble vitamins are vitamins A, [...]

Media Type
    Buy from

    Price may vary by retailers

    Work TypeBook Chapter
    Published inVitamins, Minerals and Trace Elements
    First Page1
    Last Page63
    DOIhttps://doi.org/10.69860/nobel.9786053359173.1
    LanguageENG
    Page Count52
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
    The word vitamin was first used to mean ""the amine necessary for life"". • Vitamins are organic catalysts necessary for normal body functions, growth and healthy living. They are not synthesized in the human body and must be obtained externally.
    Vitamins are classified according to their fat and water solubility. Fat-soluble vitamins are vitamins A, D, E and K, and although they are essential for health, each of them has very important functions in the body. They have many biological activities such as vision, bone, coagulation and antioxidant effects. They are released, absorbed and transported (as chylomicrons) along with dietary fats. They are stored in the liver and fatty tissue and are eliminated more slowly than water-soluble vitamins. Vitamins A and D can accumulate in the body and cause toxic effects.
    Minerals are inorganic substances needed for the body to maintain its basic functions. These substances cannot be created directly by plants and animals and are taken from the soil. Minerals are divided into two groups: macrominerals and microminerals. Macrominerals are elements that should be taken in amounts greater than 100 mg daily. Calcium, phosphorus, magnesium, sodium, chlorine and potassium are macrominerals. Deficiency or excess intake of minerals can disrupt many biological functions and cause diseases. Sodium is a mineral that plays an important role in the body. Sodium, the main cation of extracellular fluid, is involved in functions such as transport of substances across the cell membrane, fluid-electrolyte balance, and regulation of blood pressure. Sodium levels in the body are kept under control by the functioning of the kidneys and the influence of hormones. Muscle contraction begins with an increase in intracellular calcium ion concentration. It is the most abundant element in the human body after calcium. It is a component of DNA and RNA. Phosphorus plays a role in the formation of bones and teeth and the repair of tissues and cells. It is found abundantly in water in nature, but rarely in plants, especially as sodium chloride and potassium chloride. It ensures that the fluids in the body are kept in balance.

    Elif Polat (Author)
    Asst. Prof. Dr, Erzurum Technical University
    https://orcid.org/0000-0003-0042-4084
    3Dr. Elif Polat completed her undergraduate education in chemistry and received her master’s and doctoral degrees in medical biochemistry. She worked as a research assistant at Atatürk University Faculty of Medicine, Department of Medical Biochemistry. Dr. Polat has been working as an Assistant Professor at Erzurum Technical University, Faculty of Health Sciences, Department of Nutrition and Dietetics since 2020. Her academic contributions include many national and international publications and declarations. Dr. Polat’s research focuses on ischemia reperfusion, diabetes and polycystic ovary syndrome. She aims to build a bridge between these with her academic studies, medical biochemical sciences, nutrition and dietetics.

    • Alomaim, H. (2018). Eff ects of Dietary Calcium on Body Composition and Lipid Metabolism in Rats Université d’Ottawa/University of Ottaw

    • Altucci, L., & Gronemeyer, H. (2001). Th e promise of retinoids to fi ght against cancer. Nature Reviews Cancer, 1(3), 181-193

    • Balcı, C., & Toktaş, N. (2021). D Vitamini Sentezi, Metabolizmasi Ve Sağlik Üzerine Etkileri. Gazi Sağlık Bilimleri Dergisi, 6(1), 34-47.

    • Barłowska, J., Szwajkowska, M., Litwińczuk, Z., & Król, J. (2011). Nutritional value and technological suitability of milk from various animal species used for dairy production. Comprehensive reviews in food science and food safety, 10(6), 291-302.

    • Baysal, A. (2004). Beslenme. Hatiboğlu Yayınevi.

    • Belorusova, A. Y., & Rochel, N. (2016). Structural studies of vitamin D nuclear receptor ligand-binding properties. Vitamins & Horm

    • Beltran-de-Miguel, B. (2015). Estevez-Santiago R. Olmedilla-Alonso B. Assessment of dietary vitamin a intake (retinol, alpha-carotene, beta-carotene, betacryptoxanthin) and its sources in the National Survey of dietary intake in Spain (2009-2010). Int J Food Sci Nutr, 66(6), 706-712.

    • Carazo, A., Macáková, K., Matoušová, K., Krčmová, L. K., Protti, M., & Mladěnka, P. (2021). Vitamin A update: forms, sources, kinetics, detection, function, defi ciency, therapeutic use and toxicity. Nutrients, 13(5), 1703.

    • Castillo-Peinado, L. d. l. S., Calderón-Santiago, M., Herrera-Martínez, A. D., León-Idougourram, S., Gálvez-Moreno, M. Á., Sánchez-Cano, R. L., Bouillon, R., Quesada-Gómez, J. M., & Priego-Capote, F. (2022). Measuring vitamin D3 metabolic status, comparison between vitamin D defi cient and suffi cient individuals. Separations, 9(6), 141.

    • Chang, A. R., & Anderson, C. (2017). Dietary phosphorus intake and the kidney. Annual review of nutrition, 3

    • Chiricozzi, A., Panduri, S., Dini, V., Tonini, A., Gualtieri, B., & Romanelli, M. (2017). Optimizing acitretin use in patients with plaque psoriasis. Dermatologic therapy, 30(2), e12453

    • Clase, C. M., Carrero, J.-J., Ellison, D. H., Grams, M. E., Hemmelgarn, B. R., Jardine, M. J., Kovesdy, C. P., Kline, G. A., Lindner, G., & Obrador, G. T. (2020). Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney international, 97(1), 42

    • D’Ambrosio, D. N., Clugston, R. D., & Blaner, W. S. (2011). Vitamin A metabolism: an update. Nutrients, 3(1), 63-103.

    • Dawson, M. (2000). The importance of vitamin A in nutrition. Current pharmaceutical design, 6(3), 311-325

    • Dimri, U., Sharma, M., Yamdagni, A., Ranjan, R., & Zama, M. (2010). Psoroptic mange infestation increases oxidative stress and decreases antioxidant status in sheep. Veterinary parasitology, 168(3-4), 318-322

    • Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L. K., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., & Mladěnka, P. (2021). Vitamin C—sources, physiological role, kinetics, deficiency, use, toxicity, and determination. Nutrients, 13(2), 61

    • Dragnev, K. H., Petty, W. J., Shah, S. J., Lewis, L. D., Black, C. C., Memoli, V., Nugent, W. C., Hermann, T., Negro-Vilar, A., & Rigas, J. R. (2007). A proof-of-principle clinical trial of bexarotene in patients with non–small cell lung cancer. Clinical Cancer Research, 13(6), 1794-1800.

    • EFSA Panel on Dietetic Products, N., Allergies, Turck, D., Bresson, J. L., Burlingame, B., Dean, T., Fairweather‐Tait, S., Heinonen, M., Hirsch‐Ernst, K. I., Mangelsdorf, I., & McArdle, H. J. (2017). Dietary reference values for vitamin K. EFSA Journal, 15(5), e04780

    • Fiorentini, D., Cappadone, C., Farruggia, G., & Prata, C. (2021). Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutrients, 13(4), 1136.

    • Fukui, K., OMOI, N. O., Hayasaka, T., Shinnkai, T., Suzuki, S., Abe, K., & Urano, S. (2002). Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Annals of the New York Academy of Sciences, 959(1), 275-284

    • Garber, A. K., Binkley, N., Krueger, D. C., & Suttie, J. (1999). Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects. The Journal of nutrition, 129(6), 1201-1203.

    • Garcia, M., Seelaender, M., Sotiropoulos, A., Coletti, D., & Lancha Jr, A. H. (2019). Vitamin D, muscle recovery, sarcopenia, cachexia, and muscle atrophy. Nutrition, 60, 66-69.

    • Groff, J. L., & Gropper, S. S. (1999). Advanced nutrition and human metabolism. Gröber, U. (2019). Magnesium and drugs. International journal of molecular sciences, 20(9), 2094

    • Gül, H. F. (2023). Vitamin Biyokimyasının Alfabesi. Nobel Tıp Kitapları.

    • Harrington, D. J., Booth, S. L., Card, D. J., & Shearer, M. J. (2007). Excretion of the urinary 5C-and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes. The Journal of nutrition, 137(7), 1763-1768

    • He, Y.-H., Li, S.-T., Wang, Y.-Y., Wang, G., He, Y., Liao, X.-L., Sun, C.-H., & Li, Y. (2012). Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet. The Journal of nutritional biochemistry, 23(10), 1238-1244

    • Iseri, L. T., & French, J. H. (1984). Magnesium: nature’s physiologic calcium blocker. American heart journal, 108(1), 188-193.

    • Ismail, A. A., Ismail, Y., & Ismail, A. A. (2018). Chronic magnesium deficiency and human disease; time for reappraisal? QJM: An International Journal of Medicine, 111(11), 759-763.

    • Janoušek, J., Pilařová, V., Macáková, K., Nomura, A., Veiga-Matos, J., Silva, D. D. d., Remiao, F., Saso, L., Malá-Ládová, K., & Malý, J. (2022). Vitamin D: Sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites. Critical reviews in clinical laboratory sciences, 59(8), 517-554.

    • Kin Ting Kam, R., Deng, Y., Chen, Y., & Zhao, H. (2012). Retinoic acid synthesis and functions in early embryonic development. Cell & bioscience, 2, 1-14

    • L. Booth, S. (2012). Vitamin K: food composition and dietary intakes. Food & nutrition research, 56(1), 550

    • Lakshman, M. (2004). Alpha and omega of carotenoid cleavage. The Journal of nutrition, 134(1), 241S-245S

    • Li, P., Chang, X., Fan, X., Fan, C., Tang, T., Wang, R., & Qi, K. (2018). Dietary calcium status during maternal pregnancy and lactation affects lipid metabolism in mouse offspring. Scientific reports, 8(1), 16542

    • Libien, J., Kupersmith, M., Blaner, W., McDermott, M., Gao, S., Liu, Y., Corbett, J., Wall, M., & Group, N. I. I. H. S. (2017). Role of vitamin A metabolism in IIH: Results from the idiopathic intracranial hypertension treatment trial. Journal of the neurological sciences, 372, 78-84

    • Lin, X., Meng, X., & Song, Z. (2019). Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy. American journal of translational research, 11(9),

    • Lokman, N. A., Ho, R., Gunasegaran, K., Bonner, W. M., Oehler, M. K., & Ricciardelli, C. (2019). Anti-tumour effects of all-trans retinoid acid on serous ovarian cancer. Journal of Experimental & Clinical Cancer Research, 38, 1-12

    • Maiani, G., Periago Castón, M. J., Catasta, G., Toti, E., Cambrodón, I. G., Bysted, A., Granado‐Lorencio, F., Olmedilla‐Alonso, B., Knuthsen, P., & Valoti, M. (2009).Carotenoids: actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans. Molecular nutrition & food research, 53(S2), S194-S218

    • Manzotti, P., De Nisi, P., & Zocchi, G. (2008). Vitamin K in plants. Funct. Plant Sci. Biotech, 2, 29-35

    • McDowell, L., Williams, S., Hidiroglou, N., Njeru, C., Hill, G., Ochoa, L., & Wilkinson, N. (1996). Vitamin E supplementation for the ruminant. Animal Feed Science and Technology, 60(3-4), 273-296

    • Miyazawa, T., Burdeos, G. C., Itaya, M., Nakagawa, K., & Miyazawa, T. (2019). Vitamin E: regulatory redox interactions. IUBMB life, 71(4), 430-441.

    • Miyazawa, T., Shibata, A., Sookwong, P., Kawakami, Y., Eitsuka, T., Asai, A., Oikawa, S., & Nakagawa, K. (2009). Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol). The Journal of nutritional biochemistry, 20(2), 79-86.

    • Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348

    • Murcillo, J. F., & Bolaños, G. (2013). Separation of vitamin-E isomers from palm oil FAME’s by supercritical desorption. Iberoamerican Conference on Supercritical Fluids (Columbia), online conference paper: www. nupeg. ufrn. br/prosciba/prosciba2013/Papers/T2-88. pdf

    • Müdürlüğü, T. C. M. E. (2015). Gıda Teknolojisi. In Vitaminler ve Mineraller

    • Negi, P., & Roy, S. (2000). Effect of blanching and drying methods on β-carotene, ascorbic acid and chlorophyll retention of leafy vegetables. LWT-Food Science and Technology, 33(4), 295-298.

    • Niu, Z., Liu, F., Yan, Q., & Li, W. (2009). Effects of different levels of vitamin E on growth performance and immune responses of broilers under heat stress. Poultry science, 88(10), 2101-2107

    • Onat T, E. K., Sözmen Y.E. (2006). İnsan Biyokimyası. Palme Yayıncılık.

    • Perusek, L., & Maeda, T. (2013). Vitamin A derivatives as treatment options for retinal degenerative diseases. Nutrients, 5(7), 2646-2666.

    • Pilz, S., März, W., Cashman, K. D., Kiely, M. E., Whiting, S. J., Holick, M. F., Grant, W. B., Pludowski, P., Hiligsmann, M., & Trummer, C. (2018). Rationale and plan for vitamin D food fortification: a review and guidance paper. Frontiers in endocrinology, 9, 373

    • Pu, F., Chen, N., & Xue, S. (2016). Calcium intake, calcium homeostasis and health. Food Science and Human Wellness, 5(1), 8-16

    • Ramm-Fischer, A. Topische Retinoide 4.0.

    • Saldamlı, İ. (2021). Gıda Kimyası. Hacettepe Üniversitesi Yayınları

    • Sarkar, A., & Ghosh, U. (2017). Effect of extraction temperature and t antioxidant activity of. Research Journal of Recent Sciences _________________, 6(2), 10-15.

    • Shea, M. K., & Booth, S. L. (2016). Concepts and controversies in evaluating vitamin K status in population-based studies. Nutrients, 8(1), 8.

    • Shearer, M. J., & Newman, P. (2014). Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis. Journal of Lipid Research, 55(3), 345-362

    • Shibata, A., Kobayashi, T., Asai, A., Eitsuka, T., Oikawa, S., Miyazawa, T., & Nakagawa, K. (2017). High purity tocotrienols attenuate atherosclerotic lesion formation in apoE-KO mice. The Journal of nutritional biochemistry, 48, 44-50

    • Singh, U., Devaraj, S., & Jialal, I. (2005). Vitamin E, oxidative stress, and inflammation. Annu. Rev. Nutr., 25, 151-174.

    • Stafford, D. (2005). The vitamin K cycle. Journal of Thrombosis and Haemostasis, 3(8), 1873-1878

    • Tengerdy, R. P. (1990). The role of vitamin E in immune response and disease resistance. Annals of the New Y

    • Traber, M. G. (2007). Vitamin E regulatory mechanisms. Annu. Rev. Nutr., 27, 347-362

    • Traber, M. G., & Atkinson, J. (2007). Vitamin E, antioxidant and nothing more. Free radical biology and medicine, 43(1), 4-15.

    • Valdés-Ramos, R., Ana Laura, G.-L., Beatriz Elina, M.-C., & Alejandra Donaji, B.-A. (2015). Vitamins and type 2 diabetes mellitus. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 15(1), 54-63.

    • von Lintig, J. (2012). Metabolism of carotenoids and retinoids related to vision. Journal of Biological Chemistry, 287(3), 1627-1634.

    • Whang, R., & Ryder, K. W. (1990). Frequency of hypomagnesemia and hypermagnesemia: requested vs routine. Jama, 263(22

    • Wong, W.-Y., Ward, L. C., Fong, C. W., Yap, W. N., & Brown, L. (2017). Anti-inflammatory γ-and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats. European journal of nutrition, 56, 133-150

    • Wyss, A. (2004). Carotene oxygenases: a new family of double bond cleavage enzymes. The Journal of nutrition, 134(1), 246S-250S.

    • Zingg, J.-M. (2007). Vitamin E: an overview of major research directions. Molecular aspects of medicine, 28(5-6), 400-422.

    Share This Chapter!