Release Date: 2024-06-10

Effects of Vitamins on Some Neurological Diseases

Halit Diril (Author), Cuneyt Caglayan (Author)

Release Date: 2024-06-10

Vitamins are micronutrients from various food sources that the nervous system needs for proper functioning. Vitamin deficiencies or imbalances can adversely affect neuronal metabolism and lead to neurodegenerative diseases. Vitamins may have therapeutic properties in Parkinson’s disease thanks to their antioxidant and anti-inflammatory properties, while various water- and fat-soluble vitamins may help prevent amyloid beta [...]

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    Work TypeBook Chapter
    Published inNeurological Diseases and Treatments in Terms of Biochemistry
    First Page1
    Last Page16
    DOIhttps://doi.org/10.69860/nobel.9786053359357.1
    Page Count16
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing

    Vitamins are micronutrients from various food sources that the nervous system needs for proper functioning. Vitamin deficiencies or imbalances can adversely affect neuronal metabolism and lead to neurodegenerative diseases. Vitamins may have therapeutic properties in Parkinson’s disease thanks to their antioxidant and anti-inflammatory properties, while various water- and fat-soluble vitamins may help prevent amyloid beta and tau pathology in Alzheimer’s disease.

    Halit Diril (Author)
    Gaziantep University
    https://orcid.org/0000-0003-4409-8268
    3Graduated from Gaziantep University, Faculty of Science and Letters, Department of Biology. He completed his master’s and doctoral education at Gaziantep University, Institute of Health Sciences, Department of Medical Biochemistry. He has scientific studies on hormones and oxidant/antioxidants. He is currently working as a Biologist at Yüzüncü Yıl University Hospital, Biochemistry Laboratory.

    Cuneyt Caglayan (Author)
    Associate Professor, Bilecik University
    https://orcid.org/0000-0001-5608-554X
    3Graduated from Atatürk University, Faculty of Science, Department of Chemistry. He completed his master’s and doctoral education at Atatürk University, Institute of Science and Technology, Department of Biochemistry. He also completed his second doctorate in Veterinary Biochemistry at Atatürk University, Institute of Health Sciences. He has scientific studies on vitamins, hormones and oxidants/antioxidants. He is currently working as an Associate Professor at Bilecik Şeyh Edebali University, Faculty of Medicine, Department of Basic Medical Sciences, Department of Medical Biochemistry.

    • Rai SN, Singh P, Steinbusch HW, Vamanu E, Ashraf G, Singh MP. The role of vitamins in neurodegenerative disease: An update. Biomedicines. 2021;9(10):1284.

    • Bruno EJ, Ziegenfuss TN. Water-soluble vitamins: Research update. Current sports medicine reports. 2005;4:207-213.

    • Bülbül S, Sürücü M, Aşık G. Vitamin kullanım alışkanlıkları ve etkileyen faktörler. Çocuk Sağlığı ve Hastalıkları Dergisi. 2014;57(4):241-245.

    • Makkar R, Behl T, Bungau S, Zengin G, Mehta V, Kumar A, Uddin MS, Ashraf GM, Abdel-Daim MM, Arora S. Nutraceuticals in neurological disorders. International journal of molecular sciences. 2020;21(12):4424.

    • Naureen Z, Dhuli K, Medori MC, Caruso P, Manganotti P, Chiurazzi P, Bertelli M. Dietary supplements in neurological diseases and brain aging. Journal of preventive medicine and hygiene. 2022;63(2 Suppl 3):E174.

    • Schwab EDP, Queiroz R, Fiebrantz AKB, Bastos M, Bonini JS, Silva WCFNd. Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease. einstein (São Paulo). 2022;20:eRW0170.

    • Değirmenci U, Sevim S, Tamer L. Alzheimer Hastalığının Vitamin B6, B12, Folat ve Homosistein Düzeyleri ile Metilentetrahidrofolat Redüktaz (MTHFR) Gen Polimorfizmi ile İlişkisi. Van Sağlık Bilimleri Dergisi. 2023;16(3):254-261.

    • Özkay ÜD, Öztürk Y, Can Ö. Yaşlanan Dünyanin Hastaliği: Alzheimer Hastaliği. SDÜ Tıp Fakültesi Dergisi. 2011;18(1):35-42.

    • Tönnies E, Trushina E. Oxidative stress, synaptic dysfunction, and Alzheimer’s disease. Journal of Alzheimer's Disease. 2017;57(4):1105-1121.

    • Tan BL, Norhaizan ME, Liew W-P-P, Sulaiman Rahman H. Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Frontiers in pharmacology. 2018;9:402374.

    • Calderón‐Ospina CA, Nava‐Mesa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS neuroscience & therapeutics. 2020;26(1):5-13.

    • Gül ŞK, Akmansu M. Yaşlı Hastalarda Nütrisyon Desteği Nasıl Olmalı? Turkish Journal of Oncology. 2021;35(1).

    • Ramamoorthy K, Yoshimura R, Al-Juburi S, Anandam KY, Kapadia R, Alachkar A, Abbott GW, Said HM. Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation. Neurobiology of disease. 2022;171:105799.

    • Milanlioğlu A. Vitamin B12 deficiency and depression. Journal of Clinical and Experimental Investigations. 2011;2(4).

    • Green R, Allen LH, Bjørke-Monsen A-L, Brito A, Guéant J-L, Miller JW, Molloy AM, Nexo E, Stabler S, Toh B-H. Vitamin B12 deficiency. Nature reviews Disease primers. 2017;3(1):1-20.

    • Akbay GD. Alzheimer Hastalığında B12 Vitamini Eksikliği. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2019;4(3).

    • Selhub J. Homocysteine metabolism. Annual review of nutrition. 1999;19(1):217-246.

    • Miller AL. The methionine-homocysteine cycle and its effects on cognitive diseases.(Homocysteine & Cognitive). Alternative Medicine Review. 2003;8(1):7-20.

    • Van Dam F, Van Gool WA. Hyperhomocysteinemia and Alzheimer's disease: A systematic review. Archives of gerontology and geriatrics. 2009;48(3):425-430.

    • Lauer AA, Grimm HS, Apel B, Golobrodska N, Kruse L, Ratanski E, Schulten N, Schwarze L, Slawik T, Sperlich S. Mechanistic link between vitamin b12 and Alzheimer’s disease. Biomolecules. 2022;12(1):129.

    • Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration. Cochrane Database of Systematic Reviews. 2017(7).

    • Adamo AM. Nutritional factors and aging in demyelinating diseases. Genes & nutrition. 2014;9:1-9.

    • He X-B, Kim M, Kim S-Y, Yi S-H, Rhee Y-H, Kim T, Lee E-H, Park C-H, Dixit S, Harrison FE. Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1-and JMJD3-dependent epigenetic control manner. Stem cells. 2015;33(4):1320-1332.

    • İnan CM. Bazı besin ögelerinin sinir sistemi üzerine etkileri. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2021;6(1):49-58.

    • Bano S, Parihar M. Reduction of lipid peroxidation in different brain regions by a combination of α-tocopherol and ascorbic acid. Journal of neural transmission. 1997;104:1277-1286.

    • Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A. Vitamin C, aging and Alzheimer’s disease. Nutrients. 2017;9(7):670.

    • Harrison F, Hosseini A, McDonald M, May J. Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice. Pharmacology Biochemistry and Behavior. 2009;93(4):443-450.

    • Heo J-H, Hyon-Lee, Lee K-M. The possible role of antioxidant vitamin C in Alzheimer’s disease treatment and prevention. American Journal of Alzheimer's Disease & Other Dementias®. 2013;28(2):120-125.

    • Banerjee A, Khemka VK, Ganguly A, Roy D, Ganguly U, Chakrabarti S. Vitamin D and Alzheimer’s disease: neurocognition to therapeutics. International Journal of Alzheimer’s Disease. 2015;2015.

    • Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends in biochemical sciences. 2004;29(12):664-673.

    • Yılmaz M, Yılmaz N. D Vitaminin beyindeki rolü ve ilişkili nörolojik hastalıklar. Journal of Clinical & Experimental Investigations. 2013;4(3).

    • Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ. Vitamin D and cognitive function. Scandinavian Journal of Clinical and Laboratory Investigation. 2012;72(sup243):79-82.

    • Annweiler C, Llewellyn DJ, Beauchet O. Low serum vitamin D concentrations in Alzheimer's disease: a systematic review and meta-analysis. Journal of Alzheimer's Disease. 2013;33(3):659-674.

    • Mizwicki MT, Menegaz D, Zhang J, Barrientos-Durán A, Tse S, Cashman JR, Griffin PR, Fiala M. Genomic and nongenomic signaling induced by 1α, 25 (OH) 2-vitamin D 3 promotes the recovery of amyloid-β phagocytosis by Alzheimer's disease macrophages. Journal of Alzheimer's Disease. 2012;29(1):51-62.

    • Grimm MO, Mett J, Hartmann T. The impact of vitamin E and other fat-soluble vitamins on Alzheimer s disease. International journal of molecular sciences. 2016;17(11):1785.

    • Yatin SM, Varadarajan S, Butterfield DA. Vitamin E prevents Alzheimer's amyloid ß-Peptide (1-42)-induced neuronal protein oxidation and reactive oxygen species production. Journal of Alzheimer's Disease. 2000;2(2):123-131.

    • Ahmed HH. Modulatory effects of vitamin E, acetyl-l-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model. Experimental and toxicologic pathology. 2012;64(6):549-556.

    • Ishrat T, Parveen K, Hoda MN, Khan MB, Yousuf S, Ansari MA, Saleem S, Islam F. Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats. Behavioural pharmacology. 2009;20(7):567-575.

    • Anh HM, Linh DM, Dung VM, Thao DTP. Evaluating dose-and time-dependent effects of vitamin C treatment on a Parkinson's disease fly model. Parkinson's disease. 2019;2019.

    • Sahu MR, Rani L, Kharat AS, Mondal AC. Could Vitamins Have a Positive Impact on the Treatment of Parkinson’s Disease? Brain Sciences. 2023;13(2):272.

    • Goldenberg MM. Medical management of Parkinson’s disease. Pharmacy and Therapeutics. 2008;33(10):590.

    • Elkouzi A, Vedam-Mai V, Eisinger RS, Okun MS. Emerging therapies in Parkinson disease—repurposed drugs and new approaches. Nature Reviews Neurology. 2019;15(4):204-223.

    • Mischley LK, Lau RC, Bennett RD. Role of diet and nutritional supplements in Parkinson’s disease progression. Oxidative medicine and cellular longevity. 2017;2017.

    • Ciulla M, Marinelli L, Cacciatore I, Stefano AD. Role of dietary supplements in the management of Parkinson’s disease. Biomolecules. 2019;9(7):271.

    • Rekik A, Santoro C, Poplawska-Domaszewicz K, Qamar MA, Batzu L, Landolfo S, Rota S, Falup-Pecurariu C, Murasan I, Chaudhuri KR. Parkinson's disease and vitamins: a focus on vitamin B12. Journal of Neural Transmission. 2024:1-15.

    • McCarter SJ, Teigen LM, McCarter AR, Benarroch EE, Louis EKS, Savica R, editors. Low vitamin B12 and Parkinson disease: potential link to reduced cholinergic transmission and severity of disease. Mayo clinic proceedings; 2019: Elsevier.

    • Orozco-Barrios CE, Battaglia-Hsu S-F, Arango-Rodriguez ML, Ayala-Davila J, Chery C, Alberto J-M, Schroeder H, Daval J-L, Martinez-Fong D, Gueant J-L. Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra. PloS one. 2009;4(12):e8268.

    • Wu Y, Zhao Z, Yang N, Xin C, Li Z, Xu J, Ma B, Lim K-L, Li L, Wu Q. Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson’s Disease Models by Alleviating Oxidative Stress. Antioxidants. 2023;12(1):153.

    • Jia L, Wang Y, Wei W, Zhao W, Lu F, Liu F. Vitamin B12 inhibits α-synuclein fibrillogenesis and protects against amyloid-induced cytotoxicity. Food & function. 2019;10(5):2861-2870.

    • Ozer F, Meral H, Hanoglu L, Aydemir T, Yilsen M, Cetin S, Ozturk O, Seval H, Koldas M. Plasma homocysteine levels in patients treated with levodopa: motor and cognitive associations. Neurological research. 2006;28(8):853-858.

    • Paraskevas GP, Kapaki E, Petropoulou O, Anagnostouli M, Vagenas V, Papageorgiou C. Plasma levels of antioxidant vitamins C and E are decreased in vascular parkinsonism. Journal of the neurological sciences. 2003;215(1-2):51-55.

    • Barmaki H, Morovati A, Eydivandi Z, Naleshkenani FJ, Saedi S, Musavi H, Abbasi M, Hemmati-Dinarvand M. The association between serum oxidative stress indexes and pathogenesis of Parkinson’s disease in the northwest of Iran. Iranian journal of public health. 2021;50(3):606.

    • Giri B, Belanger K, Seamon M, Bradley E, Purohit S, Chong R, Morgan JC, Baban B, Wakade C. Niacin ameliorates neuro-inflammation in Parkinson’s disease via GPR109A. International journal of molecular sciences. 2019;20(18):4559.

    • Jia H, Li X, Gao H, Feng Z, Li X, Zhao L, Jia X, Zhang H, Liu J. High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease. Journal of Neuroscience Research. 2008;86(9):2083-2090.

    • Motawi TK, Sadik NA, Hamed MA, Ali SA, Khalil WK, Ahmed YR. Potential therapeutic effects of antagonizing adenosine A 2A receptor, curcumin and niacin in rotenone-induced Parkinson’s disease mice model. Molecular and cellular biochemistry. 2020;465:89-102.

    • Lv L, Tan X, Peng X, Bai R, Xiao Q, Zou T, Tan J, Zhang H, Wang C. The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease. Translational neurodegeneration. 2020;9:1-13.

    • Zhang HJ, Zhang JR, Mao CJ, Li K, Wang F, Chen J, Liu CF. Relationship between 25‐Hydroxyvitamin D, bone density, and Parkinson’s disease symptoms. Acta Neurologica Scandinavica. 2019;140(4):274-280.

    • Liu H, He Y, Beck J, da Silva Teixeira S, Harrison K, Xu Y, Sisley S. Defining vitamin D receptor expression in the brain using a novel VDRCre mouse. Journal of Comparative Neurology. 2021;529(9):2362-2375.

    • Wang X, Shen N, Lu Y, Tan K. Vitamin D receptor polymorphisms and the susceptibility of Parkinson’s disease. Neuroscience Letters. 2019;699:206-211.

    • Al‐Amin M, Bradford D, Sullivan RK, Kurniawan ND, Moon Y, Han SH, Zalesky A, Burne TH. Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment. Human Brain Mapping. 2019;40(2):394-406.

    • Schirinzi T, Martella G, Imbriani P, Di Lazzaro G, Franco D, Colona VL, Alwardat M, Sinibaldi Salimei P, Mercuri NB, Pierantozzi M. Dietary vitamin E as a protective factor for Parkinson's disease: clinical and experimental evidence. Frontiers in Neurology. 2019;10:148.

    • Coupland KG, Mellick GD, Silburn PA, Mather K, Armstrong NJ, Sachdev PS, Brodaty H, Huang Y, Halliday GM, Hallupp M. DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E in vitro. Movement Disorders. 2014;29(13):1606-1614.

    • Sies H, Stahl W, Sundquist AR. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Annals of the New York Academy of Sciences. 1992;669:7-20.

    • Icer M, Arslan N, Karadağ G. Effects of vitamin E on neurodegenerative diseases: An update. Acta Neurobiologiae Experimentalis. 2021;81.

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