Antiepileptic Medicinal Plants
Fidel Demir (Author)
Release Date: 2024-05-31
Epilepsy is a neurological disorder characterised by recurrent and spontaneous seizures. Millions of people worldwide struggle with epilepsy. There is no radical treatment for epilepsy. Current treatments are symptomatic and approximately one third of the patients show resistance to existing drugs. The majority of epilepsy patients live in countries with low socioeconomic status. It is [...]
Media Type
Buy from
Price may vary by retailers
Work Type | Book Chapter |
---|---|
Published in | Brain Health and Medicinal Plants |
First Page | 21 |
Last Page | 33 |
DOI | https://doi.org/10.69860/nobel.9786053359241.2 |
Page Count | 13 |
Copyright Holder | Nobel Tıp Kitabevleri |
License | https://nobelpub.com/publish-with-us/copyright-and-licensing |
The epileptogenic mechanism has not been solved yet. Currently used antiepileptic drugs are symptomatic and do not provide radical treatment. Modern antiepileptic drugs reduce seizure frequency but do not show antiepileptogenic properties. Experimental studies indicate that herbal compounds may show antiepileptogenic properties. In the literature on this subject, it is seen that there are many natural plants that have been studied. It is stated that antiepileptic drugs can potentially be developed from these. Based on these reasons, I aimed to explain the herbal compounds showing antiepileptic properties in the light of the literature.
Fidel Demir (Author)
MD, Selahaddin Eyyubi State Hospital
https://orcid.org/0000-0001-5510-3224
3He was born on 15.08.1991 in Bismil/Diyarbakır and is originally from Gökçebağ/Siirt. In 2016, he graduated from Dicle University Faculty of Medicine. Between 2016-2017, he worked as a family physician at Bismil Poet Cahit Sıtkı Tarancı Family Health Centre. Between 2017-2022, he completed his speciality education at Dicle University Faculty of Medicine, Department of Neurology. Between 17 March 2022 and 1 September 2023, he worked as a neurology specialist at Şırnak Silopi State Hospital. Since 1 September 2023, he has been working at Selahaddin Eyyubi State Hospital. He is married and has two children.
Ahmad N, Hui-Yin Y, Makmor-Bakry M. Mechanisms of natural products as potential antiepileptic drugs. Pak J Pharm Sci. 2022 Jul;35(4):1043-1053.
Taiwan Herbal Pharmacopeia 3rd Edition Committee (2019). Taiwan Herbal Pharmacopeia, English Version, 3rd Edn. Taiwan: Ministry Health and Welfare, 10–388.
Ameri A. The effects of Aconitum alkaloids on the central nervous system. Prog Neurobiol 1998a; 56: 211–235.
Ameri A, Gleitz J, Peters T. Aconitine inhibits epileptiform activity in rat hippocampal slices. Naunyn Schmiedebergs Arch Pharmacol 1996a; 354: 80–85.
Bhutada P, Mundhada Y, Bansod K, et al. Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. Epilepsy Behav 2010; 18: 207–210
Da Silva AFS, de Andrade JP, Bevilaqua LRM, et al. Anxiolytic-, antidepressant- and anticonvulsant-like effects of the alkaloid montanine isolated from Hippeastrum vittatum. Pharmacol Biochem Behav 2006; 85: 148–154.
Chen K, Kokate TG, Donevan SD, et al. Ibogaine block of the NMDA receptor: in vitro and in vivo studies. Neuropharmacology 1996; 35: 423–431.
Da Cruz GM, Felipe CF, Scorza FA, et al. Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms. Pharmacol Biochem Behav 2013; 104: 144–153.
Kang TH, Murakami Y, Matsumoto K, et al. Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes. Eur J Pharmacol 2002; 455: 27–34.
Charveron M, Assie MB, Stenger A, et al. Benzodiazepine agonist-type activity of raubasine, a rauwolfia serpentina alkaloid. Eur J Pharmacol 1984; 106: 313–317.
Han JY, Ahn SY, Kim CS, Yoo SK, Kim SK, Kim HC, Hong JT, Oh KW. Protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects. Biol Pharm Bull. 2012;35(9):1440–6.
Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol. 2000;59(11):1387–94.
Zhen JL, Chang YN, Qu ZZ, Fu T, Liu JQ, Wang WP. Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling. Epilepsy Behav. 2016;57(Pt A):177–84.
Tambe R, Patil A, Jain P, Sancheti J, Somani G, Sathaye S. Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy. Pharm Biol. 2017;55(1):264–8.
Khodamoradi M, Asadi-Shekaari M, Esmaeili-Mahani S, Esmaeilpour K, Sheibani V. Effects of genistein on cognitive dysfunction and hippocampal synaptic plasticity impairment in an ovariectomized rat kainic acid model of seizure. Eur J Pharmacol. 2016;786:1–9.
Amiri Gheshlaghi S, Mohammad Jafari R, Algazo M, Rahimi N, Alshaib H, Dehpour AR. Genistein modulation of seizure: involvement of estrogen and serotonin receptors. J Nat Med. 2017;71(3):537–44.
Elsayed AA, Menze ET, Tadros MG, Ibrahim BMM, Sabri NA, Khalifa AE. Effects of genistein on pentylenetetrazole-induced behavioral and neurochemical deficits in ovariectomized rats. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(1):27–36.
Kim S, Jung UJ, Oh YS, Jeon MT, Kim HJ, Shin WH, Hong J, Kim SR. Beneficial effects of silibinin against kainic acid-induced neurotoxicity in the hippocampus in vivo. Exp Neurobiol. 2017;26(5):266–77.
Kandhare AD, Mukherjee AA, Bodhankar SL. Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress. Asian Pacific J Trop Biomed. 2018;8(7):352–9.
Hong J, Lee JM, Yoon D, Jung UJ, Kim SR. No Synergistic Effect of Silibinin and Morin in a Kainic Acid-Induced Epileptic Mouse Model. J Med Food. 2020 Feb;23(2):198-202. doi: 10.1089/jmf.2019.4522. Epub 2020 Jan 8.
Nassiri-Asl M, Moghbelinejad S, Abbasi E, Yonesi F, Haghighi MR, Lotfizadeh M, Bazahang P. Effects of quercetin on oxidative stress and memory retrieval in kindled rats. Epilepsy Behav. 2013;28(2):151–5.
Sefil F, Kahraman I, Dokuyucu R, Gokce H, Ozturk A, Tutuk O, Aydin M, Ozkan U, Pinar N. Ameliorating effect of quercetin on acute pentylenetetrazole induced seizures in rats. Int J Clin Exp Med. 2014;7(9):2471–7.
Abbasi E, Nassiri-Asl M, Shafeei M, Sheikhi M. Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats. Chem Biol Drug Des. 2012;80(2):274–8.
Kumar A, Lalitha S, Mishra J. Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: possible behavioral, biochemical and mitochondrial alterations. Indian J Pharmacol. 2014;46(3):309–15.
Liu YF, Gao F, Li XW, Jia RH, Meng XD, Zhao R, Jing YY, Wang Y, Jiang W. The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. Neurochem Res. 2012;37(8):1670–80.
Woo TS, Yoon SY, dela Peña IC, et al. Anticonvulsant effect of Artemisia capillaris Herba in mice. Biomol Ther 2011; 19: 342–347.
Luszczki JJ, Glowniak K, Czuczwar SJ. Time-course and dose-response relationships of imperatorin in the mouse maximal electroshock seizure threshold model. Neurosci Res 2007; 59: 18–22.
Luszczki JJ, Andres-Mach M, Cisowski W, et al. Osthole suppresses seizures in the mouse maximal electroshock seizure model. Eur J Pharmacol 2009a; 607: 107–109.
onix_3.0::thoth | Thoth ONIX 3.0 |
---|---|
onix_3.0::project_muse | Project MUSE ONIX 3.0 |
onix_3.0::oapen | OAPEN ONIX 3.0 |
onix_3.0::jstor | JSTOR ONIX 3.0 |
onix_3.0::google_books | Google Books ONIX 3.0 |
onix_3.0::overdrive | OverDrive ONIX 3.0 |
onix_2.1::ebsco_host | EBSCO Host ONIX 2.1 |
csv::thoth | Thoth CSV |
json::thoth | Thoth JSON |
kbart::oclc | OCLC KBART |
bibtex::thoth | Thoth BibTeX |
doideposit::crossref | CrossRef DOI deposit |
onix_2.1::proquest_ebrary | ProQuest Ebrary ONIX 2.1 |
marc21record::thoth | Thoth MARC 21 Record |
marc21markup::thoth | Thoth MARC 21 Markup |
marc21xml::thoth | Thoth MARC 21 XML |