The hand and wrist are one of the most complex structures in the human body, with more than twenty joint connections and complex integrated movement segments. Therefore, knowing the anatomy of the hand and wrist well is important for the correct diagnosis of pathologies in this region, the creation of correct rehabilitation programs and the correct interpretation of the results. Pathologies of different severity and course can be seen in the hand and wrist, such as De Quarvin tendinitis, trigger finger, rheumatoid arthritis, tendon injuries and carpal tunnel syndrome, etc. When applying therapeutic exercise methods in hand and wrist diseases, the patient’s diagnosis, age, other accompanying diseases, medical condition, pain tolerance, inability to do in daily life and work, and functional status should be evaluated and the rehabilitation program should be personalized in line with the evaluation results. The stage of the disease (acute/subacute/chronic), whether there is an exacerbation, the presence of wound/scar tissue, the patient’s motor control ability, sensory disorders, the patient’s general health status and psychosocial status are other parameters that should be evaluated comprehensively and taken into consideration in treatment.As with other orthopedic problems, therapeutic exercise approaches and manual applications are an important component of the treatment for pathologies seen in the hand and wrist. Current exercise approaches and manual techniques include active/active assistive and passive hand-wrist range of motion exercises, stretching and strengthening exercises, tendon gliding, blocking exercises, place and holding exercise, traction, Mulligan mobilization, and massage approaches. The aim of exercise approaches and manual techniques applied to hand and wrist pathologies is to eliminate or prevent symptoms, problems or diseases, to increase hand and wrist functionality, to reduce the risk of injury, and to improve the person’s disease-specific and general health perception. In this section, we will present a comprehensive review of current exercise approaches and manual practices in hand-wrist pathologies and their clinical applications in the literature.