Research has highlighted the role of adipokines, signaling molecules secreted by adipose tissue, in both metabolic dysregulation associated with obesity and the neurodegenerative processes underlying AD. Key adipokines include leptin, which has neuroprotective effects, adiponectin, which has anti-inflammatory and insulin-sensitizing properties, and resistin, which is implicated in insulin resistance and may contribute to neuroinflammation and cognitive decline. Understanding the interplay between obesity, adipokines, and AD is crucial for identifying novel therapeutic strategies targeting both metabolic and cognitive impairments. This chapter aims to elucidate the relationship between AD and obesity, with a focus on selected adipokines that play pivotal roles in obesity-related pathophysiological mechanisms and neuroinflammation. Another critical pathological feature of AD is the formation of neurofibrillary tangles (NFTs), produced by hyperphosphorylated tau. In summary, The chapter shows the connections between obesity, adipokines, and AD highlights shared pathophysiological mechanisms.