The brain ventricles are a network of interconnected cavities in the brain filled with cerebrospinal fluid (CSF), which plays a crucial role in protecting and nourishing the brain. There are four primary ventricles: the two lateral ventricles located in each hemisphere, the third ventricle located in the midline between the thalami, and the fourth ventricle located between the brainstem and the cerebellum. These ventricles are connected by narrow passages, allowing the CSF to circulate. The lateral ventricles are the largest and C-shaped, extending through all lobes of the cerebral hemispheres. The third ventricle communicates with the lateral ventricles via the interventricular foramina (foramina of Monro) and with the fourth ventricle via the cerebral aqueduct (aqueduct of Sylvius). The fourth ventricle is connected to the central canal of the spinal cord. Also, it opens into the subarachnoid space through three apertures: the median aperture and the two lateral apertures. Cerebrospinal fluid (CSF) production, flow, and absorption are critical for maintaining intracranial pressure and providing essential nutrients to the brain while removing waste products. The brain ventricles play a pivotal role in the production, circulation, and CSF, essential for maintaining the brain’s homeostasis. Any disruption in the normal function of the ventricular system can lead to significant clinical conditions with serious neurological consequences. These disorders, such as hydrocephalus, intracranial hypertension, ventriculomegaly, infections, tumors, and trauma-related complications, highlight the ventricles’ clinical importance. Understanding these implications is crucial for early diagnosis and managing conditions affecting the ventricular system and overall brain health. Disorders of the ventricular system, such as hydrocephalus, can lead to significant neurological impairment due to the imbalance of CSF production and absorption, leading to increased intracranial pressure.