Urine biomarkers for bladder cancer, explored in this chapter, assess their potential in enhancing diagnostic accuracy, monitoring recurrence, and improving surveillance protocols. The chapter discusses various biomarkers like EpiCheckTM, Xpert® Bladder Cancer Monitor, ADX BladderTM, and Cxbladder, evaluating their sensitivity and specificity for detecting high-grade tumors and their integration into clinical practice as adjuncts or alternatives to traditional methods like cystoscopy.