In this section, we reviewed adjuvant intravesical chemotherapy for Non-Muscle invasive bladder cancer. Mitomycin C indicated for the treatment of bladder cancer and effective for low and intermediate-risk tumors.Epirubicin is a doxorubicin analogue. Perioperative epirubicin treatment is appropriate for patients with low-grade ,single sided and up to 3 cm diameter tumors. Gemcitabine is a chemotherapeutic intravesical agent. Intravesical gemcitabine is effective in patients with BCG-resistant disease and who refuse radical cystectomy.