Patients with metastatic prostate cancer (mPCa) often endure significant physical and psychological effects from treatment, impacting relationships, work, and overall quality of life (QoL). Common treatments like surgery, androgen deprivation therapy (ADT), radiotherapy, and chemotherapy each have unique side effects. Post-surgery, patients may face erectile dysfunction, incontinence, and other complications. Radiotherapy can lead to intestinal toxicity and secondary cancers. ADT frequently results in sexual dysfunction, cognitive decline, and increased risks of fractures and cardiovascular issues. Addressing these side effects and incorporating supportive measures, such as regular physical activity and bone health management, is crucial to enhance the QoL in mPCa patients.