1. United Nations Department of Economic and Social Affairs Population Division, World Population Ageing [homepage on the Internet], 2019. Available from https://www.un.org/en/develop-
ment/desa/ population/publications/pdf/ageing/WorldPopulationAgeing2019- Highlights.pdf
2. Beğer T, Yavuzer H. Yaşlılık ve yaşlılık epidemiyolojisi. Klinik Gelişim. 2012; 25: 1-3.https://www.sbb.gov.tr/wp-content/uploads/2020/04/YaslanmaOzelIhtisasKomisyonuRaporu.pdf
4. https://data.tuik.gov.tr/Bulten/Index?p=Dunya-Nufus-Gunu-2023-49688.
5. Przemska-Kosicka A, Childs CE, Maidens C, Dong H, Todd S, Gosney MA, et al. Age-Related Changes in the Natural Killer Cell Response to Seasonal Influenza Vaccination Are Not Influ-
enced by a Synbiotic: a Randomised Controlled Trial. Front Immunol. 2018;22 (9):591.
6. Bulut O, Kilic G, Domínguez-Andrés J, Netea MG. Overcoming immune dysfunction in the elderly: trained immunity as a novel approach. Int Immunol. 2020;32(12):741-753.
7. Niraula A, Sheridan JF, Godbout JP. Microglia Priming with Aging and Stress. Neuropsychopharmacology. 2017;42(1):318-333.
8. Javanmehr N, Saleki K, Alijanizadeh P, Rezaei N. Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases. J Neuroinflammation. 2022;19(1):273.
9. Moro-García MA, Alonso-Arias R, López-Larrea C. When Aging Reaches CD4+ T-Cells: Phenotypic and Functional Changes. Front Immunol. 2013;4:107.
10. Martín S, Pérez A, Aldecoa C. Sepsis and Immunosenescence in the Elderly Patient: A Review. Front Med (Lausanne). 2017;4:20.
11. Stauder R, Thein SL. Anemia in the elderly: clinical implications and new therapeutic concepts. Haematologica. 2014;99(7):1127-30.
12. Li Z, Zhang Z, Ren Y, Wang Y, Fang J, Yue H, et al. Aging and age-related diseases: from mechanisms to therapeutic strategies. Biogerontology. 2021;22(2):165-187.
13. Aslan D, Koç E, Çolaklar M. Yaşlıların Sağlık/Hastalık Durumlarının Toplum Sağlığı Açısından Değerlendirilmesi. Sosyoloji Araştırmaları Dergisi, 2018; 21(2): 29-48.
14. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci
Med Sci. 2004;59(3):255-63.
15. Vonnes C, El-Rady R. When You Hear Hoof Beats, Look for the Zebras: Atypical Presentation of Illness in the Older Adult. J. Nurse Pract. 2021;17(4):458-461.
16. Limpawattana P, Phungoen P, Mitsungnern T, Laosuangkoon W, Tansangworn N. Atypical presentations of older adults at the emergency department and associated factors. Arch Gerontol
Geriatr. 2016;62:97-102.
17. Shimazui T, Nakada TA, Walley KR, Oshima T, Abe T, Ogura H, JAAM FORECAST Group et al. Significance of body temperature in elderly patients with sepsis. Crit Care. 2020;24(1):387.
18. Conner T, Thompson J, Tiplady S. Sepsis in the older person. Nursing and Residential Care. 2021.23:8,1-7
19. Talebi-Taher M, Babazadeh S, Barati M, Latifnia M. Serum inflammatory markers in the elderly: are they useful in differentiating sepsis from SIRS? Acta Med Iran. 2014;52(6):438-42.
20. Angeletti S, Battistoni F, Fioravanti M, Bernardini S, Dicuonzo G. Procalcitonin and mid-regional pro-adrenomedullin test combination in sepsis diagnosis. Clin Chem Lab Med.
2013;51(5):1059-67.
21. Artero A, Inglada L, Gómez-Belda A, Capdevila JA, Diez LF, Arca A, et al. The clinical impact of bacteremia on outcomes in elderly patients with pyelonephritis or urinary sepsis: A prospective
multicenter study. PLoS One. 2018;13(1):e0191066.
22. Yañez Palma MC, Roman F, Llopis-Roca F, Fragiel M, Julián Jiménez A, Martín-Sánchez FJ, et al. Utility of the medial region of pro-adrenomodulin for the detection of true bacteremia in
elderly patients treated in the emergency department for suspected infection.Rev Esp Quimioter. 2024;37(1):78-87.
23. Bea C, Vela S, García-Blas S, Perez-Rivera JA, Díez-Villanueva P, de Gracia AI, et al. Infective Endocarditis in the Elderly: Challenges and Strategies. J Cardiovasc Dev Dis. 2022;9(6):192.
24. Osman M, Manosuthi W, Kaewkungwal J, Silachamroon U, Mansanguan C, Kamolratanakul S, et al. Etiology, Clinical Course, and Outcomes of Pneumonia in the Elderly: A Retrospective
and Prospective Cohort Study in Thailand. Am J Trop Med Hyg. 2021;104(6):2009-2016.
25. Chebib N, Cuvelier C, Malézieux-Picard A, Parent T, Roux X, Fassier T, et al. Correction to: Pneumonia prevention in the elderly patients: the other sides. Aging Clin Exp Res. 2021;33(11):3149.
26. Niederman MS. Natural enemy or friend? Pneumonia in the very elderly critically ill patient. Eur Respir Rev. 2020;29(155):200031.
27. Langer J, Welch VL, Moran MM, Cane A, Lopez SMC, Srivastava A, et al. High Clinical Burden of Influenza Disease in Adults Aged ≥ 65 Years: Can We Do Better? A Systematic Literature
Review. Adv Ther. 2023;40(4):1601-1627.
28. Tanner AR, Dorey RB, Brendish NJ, Clark TW. Influenza vaccination: protecting the most vulnerable. Eur Respir Rev. 2021 ;30(159):200258.
29. Uemura K, Ono S, Michihata N, Yamana H, Yasunaga H. Duration of influenza vaccine effectiveness in the elderly in Japan: A retrospective cohort study using large-scale population-based
registry data. Vaccine. 2023;41(19):3092-3098.
30. Global tuberculosis report 2023. Geneva: World Health Organization; 2023
31. Caraux-Paz P, Diamantis S, de Wazières B, Gallien S. Tuberculosis in the Elderly. Journal of Clinical Medicine. 2021; 10(24):5888.
32. Meintjes G, Brust JCM, Nuttall J, Maartens G. Management of active tuberculosis in adults with HIV. Lancet HIV. 2019;6(7):e463-e474.
33. Nahid P, Dorman SE, Alipanah N, Barry PM, Brozek JL, Cattamanchi A, et al. Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of
America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis. Clin Infect Dis. 2016;63(7):e147-e195.
34. Rowe TA, Juthani-Mehta M. Urinary tract infection in older adults. Aging health.2013;9(5):10.2217/ahe.13.38.
35. Durkin MJ, Schmitz V, Hsueh K, Troubh Z, Politi MC. Older adults’ and caregivers’ perceptions about urinary tract infection and asymptomatic bacteriuria guidelines: a qualitative explora-
tion. Antimicrob Steward Healthc Epidemiol. 2023;3(1):e224.
36. Falcone M, Tiseo G. Skin and soft tissue infections in the elderly. Curr Opin Infect Dis. 2023;36(2):102-108.
37. Carroll K, Dowsey M, Choong P, Peel T. Risk factors for superficial wound complications in hip and knee arthroplasty. Clin Microbiol Infect. 2014;20 (2):130-5.
38. American Academy of Orthopaedic Surgeons EvidenceBased Clinical Practice Guideline for Diagnosis and Prevention of Periprosthetic Joint Infections htps://www.aaos.org/pjicpg Published
March 11, 2019
39. Kakpovi K, Atake A, Houzou P, Diallo I, Diallo M, Koffi-Tessio V, et al. Infectious Spondylodiscitis in the Elderly in a Rheumatological Setting in Togo. Open Journal of Rheumatology and
Autoimmune Diseases. 2022; 12: 1-8.
40. Adawi M, Bragazzi NL, Watad A. (2020). Septic Arthritis in the Elderly. In: Slobodin, G., Shoenfeld, Y. (eds) Rheumatic Disease in Geriatrics. Springer,Cham.https://doi.org/10.1007/978-3-
030-44234-7_22
41. Wang AY, Machicado JD, Khoury NT, Wootton SH, Salazar L, Hasbun R. Community-acquired meningitis in older adults: clinical features, etiology, and prognostic factors. J Am Geriatr Soc.
2014;62(11):2064-70.
42. Domingo P, Pomar V, de Benito N, Coll P. The spectrum of acute bacterial meningitis in elderly patients. BMC Infect Dis. 2013;13:108.
43. Olie SE, van Zeggeren IE, Ter Horst L; I.-PACE Study Group; van de Beek D, Brouwer MC. Seizures in adults with suspected central nervous system infection. BMC Neurol. 2022;22(1):426.
44. Parisi SG, Basso M, Del Vecchio C, Andreis S, Franchin E, Dal Bello F, et al. Viral infections of the central nervous system in elderly patients: a retrospective study. Int J Infect Dis. 2016;44:8-10.
45. Muliana D, Mulia VD, Suardi HN, Puspita NA, Suryawati S. Probiotics and Their Role in Decreasing Diarrhea Prevalence in the Elderly Population:A Comprehensive Meta Analysis. Malacca
Pharm. 2024; 2: 1-9.
46. Centers for Disease Control and Prevention. National Center for HIV, Viral Hepatitis, STD, and Tuberculosis Prevention. NCHHSTP AtlasPlus. https://www.cdc.gov/nchhstp/atlas/index.ht.
47. Fu L, Tian T, Wang B, Lu Z, Bian J, Zhang W, et al. Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60-89 years from 1990 to 2019:
results from the Global Burden of Disease Study 2019. Lancet Healthy Longev. 2024;5(1):e17-e30.
48. Marcus JL, Leyden WA, Alexeeff SE, Anderson AN, Hechter RC, Hu H, et al. Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV
Infection, 2000-2016. JAMA Netw Open. 2020;3(6):e207954.
49. Pourcher V, Gourmelen J, Bureau I, Bouee S. Comorbidities in people living with HIV: An epidemiologic and economic analysis using a claims database in France. PLoS One.
2020;15(12):e0243529.
50. Yadav BK, Pannu AK, Kumar R, Rohilla M, Kumari S. Fever of Unknown Origin in Older Adults: A Prospective Observational Study from North India. J Assoc Physicians India. 2021;69(10):11-
12.
51. Adult immunization schedule by age-Recommendations for ages 19 years or older, United States, 2024. https://www.nfid.org/immunization/us-vaccine-recommendations/adult-immunizati-
on-schedule-19-years-and-older/ (Erişim tarihi: 01.04.2024)
52. Schramm L, Byrne MK, Sweetnam T. Antibiotic Misuse Behaviours of Older People: Confirmation of the Factor Structure of the Antibiotic Use Questionnaire. Antibiotics (Basel).
2023;12(4):718.
53. Zerah L, Henrard S, Wilting I, O’Mahony D, Rodondi N, Dalleur O, et al. Prevalence of drug-drug interactions in older people before and after hospital admission: analysis from the OPERAM
trial. BMC Geriatr. 2021;21(1):571. ed changes on burns patients. Burns 2015;41:39-48.