Release Date: 2024-06-12

SARS-COV-2 and Brain Disease

Fidel Demir (Author)

Release Date: 2024-06-12

Severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) primarily affects the lungs and causes respiratory distress, but also affects all other tissues, especially the brain and heart. COVID-19 has caused devastation, maiming and killing millions of people worldwide. It is crucial to elucidate the factors involved in the development of this pandemic to prevent the [...]

Media Type
    Buy from

    Price may vary by retailers

    Work TypeBook Chapter
    Published inBrain Biochemistry and Its Disease
    First Page231
    Last Page245
    DOIhttps://doi.org/10.69860/nobel.9786053359371.13
    Page Count15
    Copyright HolderNobel Tıp Kitabevleri
    Licensehttps://nobelpub.com/publish-with-us/copyright-and-licensing
    Severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) primarily affects the lungs and causes respiratory distress, but also affects all other tissues, especially the brain and heart. COVID-19 has caused devastation, maiming and killing millions of people worldwide.
    It is crucial to elucidate the factors involved in the development of this pandemic to prevent the emergence of similar pandemics in the coming years. Analysing the transmission routes, mechanism of action, treatment approaches and prognostic factors of SARS-CoV-2 is imperative for the future of humanity. Patients may experience neurological symptoms such as anosmia, wetusia, encephalopathy, meningitis and cerebral vascular events. Almost every symptom related to the nervous system can be seen in SARS-CoV-2 patients. In this article, I aimed to explain the neurological effects of SARS-CoV-2 in the light of the literature.

    Fidel Demir (Author)
    Selahaddin Eyyubi State Hospital
    https://orcid.org/0000-0001-5510-3224
    3He was born on 15.08.1991 in Bismil/Diyarbakır and is originally from Gökçebağ/Siirt. In 2016, he graduated from Dicle University Faculty of Medicine. Between 2016-2017, he worked as a family physician at Bismil Poet Cahit Sıtkı Tarancı Family Health Centre. Between 2017-2022, he completed his speciality education at Dicle University Faculty of Medicine, Department of Neurology. Between 17 March 2022 and 1 September 2023, he worked as a neurology specialist at Şırnak Silopi State Hospital. Since 1 September 2023, he has been working at Selahaddin Eyyubi State Hospital. He is married and has two children.

    • Xia H, Lazartigues E. Angiotensin-converting enzyme 2 in the brain: properties and future directions. J Neurochem. 2008;107(06):1482–1494.

    • Yachou Y, El Idrissi A, Belapasov V, Ait Benali S. Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients. Neurol Sci. 2020;41(10):2657–2669.

    • Generoso J S, Barichello de Quevedo J L, Cattani M et al. Neurobiology of COVID-19: how can the virus affect the brain? Br J Psychiatry. 2021;43(06):650–664.

    • Mukerji S S, Solomon I H. What can we learn from brain autopsies in COVID-19? Neurosci Lett. 2021;742:135528.

    • Bolay H, Gül A, Baykan B. COVID-19 is a Real Headache. Headache. 2020;60(7):1415–1421.

    • Barut BO, Altun IG. COVID-19 ile İlişkili Nörolojik Komplikasyonlar. South Clin Ist Euras. 2020;31(1):26–30.

    • Boldrini M, Canoll P D, Klein R S. How COVID-19 Affects the Brain. JAMA Psychiatry. 2021;78(06):682–683.

    • Kempuraj D, Selvakumar G P, Ahmed M Eet al. COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation Neurosci a Rev J bringing Neurobiol Neurol psychiatry 202026(5–6):402–414.

    • Saposnik G., Barinagarrementeria F., Brown R.D., Jr., Bushnell C.D., Cucchiara B., Cushman M. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(4):1158–1192.

    • Goodin D. The epidemiology of multiple sclerosis: insights to a causal cascade. Handbook of clinical neurology 2016;138:173-206.

    • Lim KH, Yang S, Kim SH,. et al. Elevation of ACE2 as a SARS-CoV-2 entry receptor gene expression in Alzheimer's disease. J Infect 2020;81:e33–e34.

    • Boutoleau-Bretonnière C, Pouclet-Courtemanche H, Gillet A,. et al. The effects of confinement on neuropsychiatric symptoms in Alzheimer's disease during the COVID-19 crisis. J Alzheimers Dis 2020;76:41–47.

    • El Haj M, Altintas E, Chapelet G,. et al. High depression and anxiety in people with Alzheimer's disease living in retirement homes during the covid-19 crisis. Psychiatry Res 2020;291:113294.

    • Huang Y, E: Mahley RW. Apolipoprotein,. Structure and function in lipid metabolism,neurobiology, and Alzheimer's diseases. Neurobiol Dis 2014;72 PtA:3–12.

    • Kuo CL, Pilling LC, Atkins JL,. et al. APOE e4 genotype predicts severe COVID-19 in the UK Biobankcommunity cohort. J Gerontol A Biol Sci Med Sci 2020;75:2231–2232.

    Share This Chapter!