Genetic Phenotypes of Idiopathic Pulmonary Fibrosis
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Approximately 10-20% of idiopathic pulmonary fibrosis cases have a familial component, suggesting a strong genetic influence. While most cases are sporadic, familial cases provide critical insights into genetic predispositions and mechanisms. TERT and TERC mutations which encode components of telomerase, are among the most common in familial idiopathic pulmonary fibrosis. They lead to shortened telomeres [...]
