One of the main subjects of anatomy education is muscular system anatomy. Muscular system anatomy is the set of muscles that form the skeletal system in the human body and enable the body to move. In this section, the abdominal region extending between the diaphragm above and the pelvis below is discussed. Abdominal muscles and their clinical importance are explained. First of all, general information about the abdominal area is given. Then, topics such as abdominal wall topography, anterior – lateral – posterior abdominal wall anatomy and clinical information are explained respectively. In the anatomy of the anterior- lateral- posterior abdominal wall is explained the anterolateral wall muscles of the abdomen (external abdominal oblique muscle, internal abdominal oblique muscle, cremaster muscle, transversus abdominis muscle, rectus abdominis muscle, and pyramidalis muscle), and posterior wall muscles of the abdomen (quadratus lumborum muscle, iliac muscle, psoas major muscle, and psoas minor muscle), neural innervation of the muscles, their vessels (artery, vein, and lymphatic), the functions of the muscles, and the fascia layer surrounding the muscles and their extensions. At the same time, at the end of the topic, clinical information about this region is given and its connection with clinical situations and its importance in human life are tried to be emphasized. At the same time, at the end of the topic, clinical information about this region is given and its connection with clinical situations and its importance in human life are tried to be emphasized. At the end of the chapter, clinical information is given about abdominal muscle palpations, the clinical importance of fascial spaces in the abdominal wall, abdominal surgical interventions and incisions, hernias, abscesses and abdominal pain. While clinical information about abdominal muscles is given, the most common conditions encountered in the clinic are mentioned. A lot of research was done and various sources were used to write this section. The information in this section appeals to all readers who are interested in the abdominal muscles and clinic.